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Selected Topics In Nanomedicine : Thomas Ming Swi Chang :

Impedimetric biosensors for medical applications : current progress and challenges. Computer modeling in bioengineering : theoretical background, examples and software. Future medical engineering based on bionanotechnology : proceedings of the final symposium of the Tohoku University 21st Century Center of Excellence Program, Sendai International Center, Japan Ja.

Mathematical methods in scattering theory and biomedical engineering : proceedings of the 7th International Workshop, Nymphaio, Greece, September Biomaterials for tissue engineering applications : a review of the past and future trends. Biomedical Engineering Systems and Technologies. In our department of Biomedical Engineering, you can study all of these fields, so it is an ideal department in which to study bioelectronics.

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One of our current research topics is the induced contraction of tissue-engineered skeletal muscle, using electric fields. We are working on applications where tissue-engineered muscles can be used as actuators, and are also developing special forms of cellulose, derived from plant cell walls, for use as ecological liquid crystal display devices. The use of tissue-engineered skeletal muscle is a promising strategy for the reconstruction of skeletal muscle loss caused by tumor ablations or accidental injury.

This novel material may also be applicable for actuators to drive machinery such as prostheses and micro-machines.

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However, construction of mature muscle tissue in vitro is still a major challenge. We are developing tissue-engineered skeletal muscle from cultured myoblasts seeded in a 3D scaffold. In the course of our research, we evaluate the effect that electrical pulse stimulation has on the isometric contractile force of tissue-engineered muscle, as well as its histological and biochemical properties. We are also developing a scaffold made of acellular biological tissue, for the regeneration of vascular, cardiac, and adipose tissues.

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We have invented a new technology for decellularization, using ultrahigh pressure and rinsing under microwave irradiation, which is registered world-wide. Many functional foods have lifesaving properties.

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Food provides vital nutritional support for our bodies, and functional foods that support homeostasis, helping metabolism and bodily functions achieve balance, are one of several areas experiencing rapid growth. One consequence of changes in eating habits is increased risk of life-threatening diseases such as diabetes, hypertension and cardiovascular disease. Thus, there is an increasing demand for functional foods.

The goal of our laboratory is to explore novel functional foods, and contribute to the maintenance and development of better health for people everywhere. Many biological phenomena such as genes and proteins are being clarified at the molecular level.

This increase in knowledge is being used in various fields, extending even to engineering and agriculture, as well as medicine. We are investigating the perception of "pain" on a molecular level by using methods derived from biochemistry, molecular biology, and cell biology, to better understand the molecular basis of neurological functions. Pain often outlasts its usefulness as a warning, and becomes chronic after tissue damage and nerve injury. Chronic pain causes dynamic changes such as gene expression, cellular responses, and plasticity observed in neural circuits.

We have isolated several molecules that block the nociception action the physiological system causing the sensation of pain , using high-performance affinity nano-beads, and are studying the action of these molecules in gene-deficient mice. We are also developing a monitoring system for dynamic biological processing in living cells. Our laboratory research focuses on biomanufacturing processes that take advantage of bioreactions and biofunctions, from the production of useful substances using microorganisms to the creation of tissues that contribute to regenerative medicine.

Bioprocess engineers, one of the resources required for research, development and manufacturing in the fermentative food, chemical, pharmaceutical and regenerative medicine industries, must understand bioreaction characteristics and conduct engineering design, construction, and optimization of production processes from the kinetics and materials balance viewpoint.

Additionally, understanding and identifying the main parameters that govern the phenomena of interest, and controlling these parameters to readily manipulate the phenomena, are required. Our research focus is on all the tools and technologies essential for these activities.

Nanomedicine shines light on combined force of nanomedicine and regenerative medicine

Advanced technology can contribute to solving difficult problems in the field of medicine. One topic of our research is the fabrication of prosthetic venous valves, using electrospinning, for percutaneous treatment of chronic venous insufficiency CVI. Nanofiber scaffolds produced by electrospinning are useful for fabricating fibrous biomaterials because the size of their fibers is similar to that of the fibers that make up the extracellular matrix of native tissues and organs. Thus, electrospinning has great potential in the field of tissue engineering.

Some other topics we study include protein transduction into cells, to control cell behavior and differentiation, and the synthesis of polyphenols by enzymatic polymerization. These polyphenols are transducted into cells in a manner similar to that of proteins, which facilitates their use in novel methods for controlling cell behavior and differentiation. We hope to contribute to human health by merging advanced technology and medicine, as described above. Our physiology lab investigates how animals respond to environmental stresses and manage to keep their internal environment fairly constant.

Living creatures experience heat stress in summer, cold stress in winter, and microbial infection is also a kind of environmental stress.

Cover Art – Biomaterials, Cancer Nanomedicine and Macroporous Hydrogels

In response to these stresses, animals exhibit various anti-stress responses that are controlled by the brain, although the precise mechanisms remain unclear. Recent advances in bioscience have provided valuable information and tools to investigate these phenomena. For example, molecules that are essential to thermal sensation are identified as belonging to TRP ion channel families.